Here's an interesting view on the 22 that I thought you might like:
https://www.full30.com/video/ed51c74dfbd160b6b56a55015d428855
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Health, Fitness, Non-Apparatus Exercise, Unarmed Self-Defense, Firearms Self Defense
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Health, Fitness, Non-Apparatus Exercise, Unarmed Self-Defense, Firearms Self Defense
My wife's gun is a Ruger LCR revolver in 22LR. She won't move up in caliber but to her credit she has tried an LCR in 22 WMR, Kel-Tec P-32, Beretta Tomcat .32, Glock 42 380acp and a few others. But in the end she is confident/competent/comfortable with her 8-shot LCR. And she is very able with it for sure. We did ammo testing to determine the best round and CCI Velocitors worked best. I am comfortable with her choice.